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KMID : 1100720230430020196
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Annals of Laboratory Medicine
2023 Volume.43 No. 2 p.196 ~ p.199
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Emergence of NDM-1-producing Pseudomonas aeruginosa Sequence Type 773 Clone: Shift of Carbapenemase Molecular Epidemiology and Spread of 16S rRNA Methylase Genes in Korea
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Choi Yu-Jeong
Kim Young-Ah
Kim Jung-Lim
Jeong Seok-Hoon
Shin Jong-Hee
Shin Kyeong-Seob
Shin Jeong-Hwan
Kim Young-Ree
Kim Hyun-Soo
Uh Young
Ryoo Nam-Hee
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Abstract
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Imipenemase (IMP)-6?producing Pseudomonas aeruginosa sequence type (ST) 235 is a dominant clone of carbapenemase-producing P. aeruginosa (CPPAE) in Korea. As part of the Antimicrobial Resistance Surveillance System in Korea, we found an increase in the carbapenem resistance rate of P. aeruginosa isolates from blood cultures and a shift in the molecular epidemiology of CPPAE. A total of 212 non-duplicated P. aeruginosa blood isolates were obtained from nine general hospitals and two nursing homes. Twenty-four isolates were identified as CPPAE. We observed the emergence of the NDM-1 P. aeruginosa ST 773 clone (N=10), mostly from Gyeongsang Province. The IMP-6 ST 235 clone (N=11) was detected in all provinces. CPPAE isolates showed very high resistance rates to amikacin, and all NDM-1 P. aeruginosa strains carried rmtB. This is the first nationwide surveillance of the recently emerged NDM-1?producing P. aeruginosa ST773 clone in Korea. Continuous surveillance is necessary to prevent the infection and transmission of carbapenem- and amikacin-resistant P. aeruginosa in Korea.
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KEYWORD
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Pseudomonas aeruginosa, Molecular Epidemiology, β-lactamase NDM-1, Sequence type 773, Amikacin, 16S rRNA methylase gene
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